Table of Contents
Early Nutrition and Programming of Obesity
Obesity - the Statistics
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Programming
The Thrifty Phenotype Hypothesis (Hales & Barker 1992)
Early Environment versus Adult Environment
Human Studies
Interaction Between Weight at 1 Year and Glucose Tolerance
The Dutch Hunger Winter
120 min Plasma Glucose
Animal Studies
Cafeteria and chow fed rats
Systolic Blood Pressure in 12 Month Old Female Rats
Systolic Blood Pressure in 12 Month Old Female Rats
Systolic Blood Pressure in 12 Month Old Female Rats
Conclusion (1)
Does early nutrition influence susceptibility to obesity?
Human Studies
Evidence
Are there critical time windows?
Is the postnatal period a critical time window?
What are the mechanisms underlying postnatal catch up growth?
Animal Studies
Evidence
Questions/Priorities for Future Research
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